What is Spravato? Spravato (esketamine)is a medication that comes as a nasal spray. It can be used to treat adults with treatment-resistant depression (TRD)TRD means you have tried typical antidepressants but did not see the expected results. Contact Us Make Your Turn offers Spravato treatment at our Monroe MI and Toledo OH locations for people who meet criteria for TRD. Use the Contact Us form or call the office to get started. More information You can find more videos like these on the Spravato YouTube Channel